NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody (FITC)
455€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx273582
tested applications
WB, IHC, IF/ICC
Description
NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC against NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 4°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96EB6 |
| Gene ID | 23411 |
| Alias | SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1 |
| Background | Antibody anti-SIRT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders
Related Products
NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 1 (S.
Ver Producto
Human NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) CLIA Kit
Human NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1).
Ver Producto
NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody (FITC)
SIRT1 Antibody (FITC) is a Rabbit Polyclonal against SIRT1 conjugated to FITC.
Ver Producto