Human Sirtuin 1 (SIRT1) CLIA Kit
643.5€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Sirtuin 1 (SIRT1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196269
tested applications
CLIA
Description
Human Sirtuin 1 (SIRT1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Sirtuin 1 (SIRT1).
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Sirtuin 1 (SIRT1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 62.5 pg/ml - 4000 pg/ml |
| Sensitivity | 37.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1 |
| Background | CLIA Kits SIRT1 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders
Related Products
Sirtuin 1 (SIRT1) Antibody
Sirtuin 1 (SIRT1) Antibody is a Mouse Monoclonal antibody against Sirtuin 1 (SIRT1).
Ver Producto
Rat Sirtuin 1 (SIRT1) CLIA Kit
Rat Sirtuin 1 (SIRT1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Ver Producto
Human Sirtuin 1 (SIRT1) ELISA Kit
Human Sirtuin 1 (SIRT1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sirtuin 1 concentrations in tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Ver Producto