NAD-Dependent Protein Deacetylase Sirtuin-1 (SirT1) Antibody
377€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
NAD-Dependent Protein Deacetylase Sirtuin-1 (SirT1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012039
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
NAD-Dependent Protein Deacetylase Sirtuin-1 (SirT1) Antibody is a Rabbit Polyclonal antibody for the detection of SIRT1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: NAD-Dependent Protein Deacetylase Sirtuin-1 (SirT1) Immunogen: sirtuin (silent mating type information regulation 2 homolog) 1 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 130 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96EB6 |
| Gene ID | 23411 |
| OMIM | 604479 |
| Alias | SIR2,SIR2L1,SIR2alpha,SIR2-like protein 1,Hsir2,NAD-dependent protein deacylase sirtuin-1 |
| Background | Antibody anti-SIRT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SIRT1 is a NAD+-dependent deacetylase and member of the sirtuin family that regulates cellular processes including gene expression, metabolism, DNA repair, and aging by removing acetyl groups from target proteins SIRT1 is highly expressed in various tissues, including the liver, brain, and skeletal muscle, where it modulates the activity of transcription factors such as p53, FOXO, NF-κB, and PPARγ coactivator-1α (PGC-1α) SIRT1 promotes cellular survival during stress by enhancing DNA repair, suppressing apoptosis, and regulating energy metabolism through mitochondrial biogenesis and fatty acid oxidation Activation of SIRT1 is associated with increased longevity and protection against age-related diseases such as type 2 diabetes, cardiovascular disease, neurodegeneration, and cancer Compounds like resveratrol act as SIRT1 activators to improve metabolic health by enhancing insulin sensitivity and mitochondrial function SIRT1 also inhibits inflammation by deacetylating NF-κB and reducing pro-inflammatory cytokine production, making it a key target for therapies in metabolic, inflammatory, and age-associated disorders
Productos relacionados
NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody
SIRT1 Antibody is a Rabbit Polyclonal antibody against SIRT1. This gene encodes a member of the sirtuin family of protei…
Ver producto
NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) Antibody
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin…
Ver producto NAD-Dependent Protein Deacetylase Sirtuin-1 (SirT1) Antibody
NAD-Dependent Protein Deacetylase Sirtuin-1 (SirT1) Antibody is a Rabbit Polyclonal antibody for the detection of SIRT1.…
Ver producto