Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein
234€ (1 µg)
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Name
Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx263452
Tested Applications
SDS-PAGE
Description
SIT1 is a recombinant protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | SIT1 |
| Assay Type | Activity: Not tested |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 1 µg |
| Size 2 | 5 µg |
| Size 3 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | Q9Y3P8 |
| Alias | SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1 |
| Background | Protein SIT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.
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