Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein SIT1
proveedor
Abbexareference
abx069095Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 22.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser2-Pro175 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SIT1
dry ice
No
availability
Shipped within 5-7 working days.
alias
SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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