Name: Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein
Brand: Abbexa
SKU: abx069095
Price: 225 EUR
Availability: OnlineOnly

Background

Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.

Características del producto

origin

Rat

host

E. coli

immunogen target

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)

host

E. coli

conjugation

Unconjugated

form

Lyophilized

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

1 mg

expression

Recombinant

purity

> 97%

buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

SIT1

dry ice

availability

Shipped within 5-7 working days.

alias

SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1

uniprot id

https://www.uniprot.org/uniprotkb/Q5M869

note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.

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Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody

proveedor

Abbexa

reference

abx029063

Tested Applications

ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Negatively regulates TCR (T-cell antigen receptor) mediated signaling in T-cells. Involved in positive selection of T-ce...

250€ (80 µl)