Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein

Este producto es parte de SIT1 - Signaling threshold-regulating transmembrane adapter 1
Rat Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein SIT1

proveedor

Abbexa

reference

abx069095

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 22.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser2-Pro175 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

SIT1


dry ice

No


availability

Shipped within 5-7 working days.


alias

SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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