Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody

Name: Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1) Antibody
Brand: Abbexa
SKU: abx433276
Price: 273 EUR
Availability: OnlineOnly

Este producto es parte de SIT1 - Signaling threshold-regulating transmembrane adapter 1

Pida mas información

935106861

info@markelab.com

Precio

273€ (200 µl)

Antibody anti-SIT1

proveedor

Abbexa

reference

abx433276

Tested Applications

P-ELISA

reactivity

status

RUO

clonality

Polyclonal

Descripción

SIT1 Antibody is a Goat Polyclonal antibody against SIT1.

Background

Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1), also known as SIT, is an immunoregulatory protein primarily expressed in T cells. It acts as a transmembrane adaptor involved in modulating T-cell receptor (TCR) signaling by interacting with key intracellular signaling molecules such as Src family kinases and SH2 domain-containing phosphatases. SIT1 fine-tunes immune responses by negatively regulating TCR-mediated activation, thus maintaining immune tolerance and preventing overactivation that could lead to autoimmune diseases. Its dysregulation is associated with immune disorders and may affect T-cell maturation and peripheral immune homeostasis.

Características del producto

clonality

Polyclonal

immunogen target

Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)

host

Goat

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

P-ELISA

purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

recommended dilution

P-ELISA: 1/2000. Optimal dilutions/concentrations should be determined by the end user.

buffer

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.

size 1

200 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SIT1

dry ice

availability

Shipped within 5-10 working days.

alias

SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1

gene id

https://www.ncbi.nlm.nih.gov/gene/27240

NCBI accession

NP_055265.1

note

Concentration: 0.5 mg/ml -

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