Signal-Transducing Adaptor Protein 2 (STAP2) Antibody
416€ (200 µl)
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935106861
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name
Signal-Transducing Adaptor Protein 2 (STAP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430608
tested applications
P-ELISA, WB, IHC
Description
STAP2 Antibody is a Goat Polyclonal antibody against STAP2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal-Transducing Adaptor Protein 2 (STAP2) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 55620 |
| NCBI Accession | NP_060190.2, NP_001013863.1 |
| Alias | STAP-2,Breast tumor kinase substrate,BRK substrate,STAP2,BKS |
| Background | Antibody anti-STAP2 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Signal-transducing adaptor protein 2 (STAP2) is an adaptor protein that plays a significant role in intracellular signaling pathways by linking various receptors to downstream effectors, particularly within immune and inflammatory responses. It contains a PH domain, SH2 domain, and a proline-rich region, which facilitate its interaction with tyrosine-phosphorylated proteins and its localization to membrane-associated signaling complexes. STAP2 is implicated in the regulation of cytokine signaling pathways, such as those mediated by STAT3 and STAT5, influencing processes like cell survival, proliferation, and differentiation. It has been shown to interact with components of the T-cell receptor complex and Fc receptors, modulating immune responses and contributing to signal transduction in lymphocytes and macrophages. Dysregulation of STAP2 expression has been linked to pathological conditions, including autoimmune diseases, chronic inflammation, and cancer, where it may promote oncogenic signaling or alter immune surveillance. Additionally, STAP2 has been associated with metabolic regulation, as it can influence insulin signaling and adipocyte differentiation. Post-translational modifications of STAP2, such as phosphorylation and ubiquitination, regulate its activity and interaction networks, highlighting its role as a versatile adaptor in multiple signaling contexts.
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