Signal Regulatory Protein Beta 1 (SIRPB1) Antibody (Biotin)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
SIRPB1 Antibody (Biotin) is a Rabbit Polyclonal against SIRPB1 conjugated to Biotin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal Regulatory Protein Beta 1 (SIRPB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00241 |
| Gene ID | 10326 |
| NCBI Accession | NP_001077379.1, NM_001083910.3, NP_001317568.1, NM_001330639.1, NP_006056.2, NM_006065.4 |
| OMIM | 603889 |
| Alias | CD172 antigen-like family member B,CD172b,SIRP-BETA-1 |
| Background | Antibody anti-SIRPB1 |
| Status | RUO |
Descripción
Signal regulatory protein beta-1 (SIRPB1) is a transmembrane glycoprotein that is part of the signal regulatory protein (SIRP) family within the immunoglobulin superfamily (IgSF). SIRPB1 is primarily expressed on myeloid cells, such as macrophages, dendritic cells, and granulocytes, and functions as an activating receptor involved in immune regulation, phagocytosis, and cellular signaling. Unlike SIRPA, another family member which interacts with CD47 to deliver inhibitory signals to prevent “self” cell phagocytosis, SIRPB1 typically serves as an activating receptor and does not interact directly with CD47. SIRPB1 plays a role in modulating immune responses, particularly through its association with DAP12 (DNAX activation protein of 12 kDa), an adaptor molecule containing immunoreceptor tyrosine-based activation motifs (ITAMs). Upon activation, SIRPB1 influences signaling cascades that lead to pro-inflammatory cytokine release, phagocytosis, and cellular migration, especially in response to pathogens or tissue injury. Because of its involvement in immune activation, SIRPB1 has become of interest in cancer, infectious diseases, and inflammatory disorders.
Related Products
Recombinant Human SIRPB1
Ver Producto
Signal Regulatory Protein Beta 1 (SIRPB1) Antibody
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Ver Producto
Signal Regulatory Protein Beta 1 (SIRPB1) Antibody
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes (By similarity).
Ver Producto