Signal-regulatory protein beta-1 isoform 3 (SIRPB1) Antibody (Biotin)
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Description
Signal-regulatory protein beta-1 isoform 3 (SIRPB1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin for the detection of Human SIRPB1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Signal-regulatory protein beta-1 isoform 3 (SIRPB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5TFQ8 |
| NCBI Accession | NP_001129316.1 |
| Alias | CD172 antigen-like family member B,CD172b,SIRP-BETA-1 |
| Background | Antibody anti-SIRPB1 |
| Status | RUO |
Descripción
Signal regulatory protein beta-1 (SIRPB1) is a transmembrane glycoprotein that is part of the signal regulatory protein (SIRP) family within the immunoglobulin superfamily (IgSF). SIRPB1 is primarily expressed on myeloid cells, such as macrophages, dendritic cells, and granulocytes, and functions as an activating receptor involved in immune regulation, phagocytosis, and cellular signaling. Unlike SIRPA, another family member which interacts with CD47 to deliver inhibitory signals to prevent “self” cell phagocytosis, SIRPB1 typically serves as an activating receptor and does not interact directly with CD47. SIRPB1 plays a role in modulating immune responses, particularly through its association with DAP12 (DNAX activation protein of 12 kDa), an adaptor molecule containing immunoreceptor tyrosine-based activation motifs (ITAMs). Upon activation, SIRPB1 influences signaling cascades that lead to pro-inflammatory cytokine release, phagocytosis, and cellular migration, especially in response to pathogens or tissue injury. Because of its involvement in immune activation, SIRPB1 has become of interest in cancer, infectious diseases, and inflammatory disorders.
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