Sialic Acid-Binding Ig-Like Lectin 8 (SIGLEC8) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Sialic Acid-Binding Ig-Like Lectin 8 (SIGLEC8) Antibody is a Human Monoclonal antibody for the detection of Sialic Acid-Binding Ig-Like Lectin 8 (SIGLEC8) in Human samples.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sialic Acid-Binding Ig-Like Lectin 8 (SIGLEC8) |
| Host | Human |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | J926 |
| Purity | > 95% |
| Purification | Purified by Protein A/G affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NYZ4 |
| Gene ID | 27181 |
| NCBI Accession | NP_055257.2 |
| Alias | SAF2,SIGLEC-8,SIGLEC8L,Sialoadhesin family member 2 |
| Background | Antibody anti-SIGLEC8 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Related Products
Human SIGLEC8 (Sialic Acid Binding Ig Like Lectin 8) ELISA Kit
Ver Producto
Human SIGLEC8 (Sialic Acid Binding Ig Like Lectin 8) QuickTest ELISA Kit
Ver Producto
Sialic Acid Binding Ig Like Lectin 8 (SIGLEC8) Antibody
SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2, 3-linked sialic acid. and also binds to alpha2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.
Ver Producto