Sialic Acid Binding Ig Like Lectin 5/14 (SIGLEC5/SIGLEC14) Antibody
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Description
Sialic Acid Binding Ig Like Lectin 5/14 (SIGLEC5/SIGLEC14) Antibody is a Mouse Monoclonal antibody against Sialic Acid Binding Ig Like Lectin 5/14 (SIGLEC5/SIGLEC14).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 5/14 (SIGLEC5/SIGLEC14) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC, FCM, IP |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15389, Q08ET2 |
| Alias | CD170,OBBP2,CD33L2,OB-BP2,SIGLEC-5,Obesity-binding protein 2,CD33 antigen-like 2 |
| Background | Antibody anti-SIGLEC5 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
SIGLEC5 is an inhibitory receptor expressed on monocytes, neutrophils, and B cells. It binds to sialic acid-containing glycans on host and microbial surfaces, modulating immune responses to avoid excessive inflammation. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), SIGLEC5 dampens activation signals and helps maintain immune tolerance. This protein also plays a role in preventing inappropriate immune responses during pregnancy and infection. Genetic fusion events between SIGLEC5 and SIGLEC14 have been noted, affecting the functional balance between activation and inhibition. SIGLEC5 is studied for its involvement in autoimmune diseases and infections.
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