SH2 Domain Containing 1B (SH2D1B) Antibody (HRP)
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Description
SH2D1B Antibody (HRP) is a Rabbit Polyclonal against SH2D1B conjugated to HRP.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 Domain Containing 1B (SH2D1B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14796 |
| Gene ID | 117157 |
| NCBI Accession | NP_444512.2, NM_053282.4 |
| OMIM | 608510 |
| Alias | SH2D1B, EAT2 |
| Background | Antibody anti-SH2D1B |
| Status | RUO |
Descripción
SH2D1B, also known as EAT-2 (EWS-FLI1-activated transcript 2), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM family receptors, particularly in innate immune cells like NK cells, macrophages, and dendritic cells. It binds to SLAM receptors and modulates their signaling, influencing NK cell cytotoxicity, macrophage activation, and cytokine production. SH2D1B promotes immune responses by enhancing IFN-γ production, immune synapse formation, and innate immune cell activation. It functions as a positive regulator of SLAM signaling, in contrast to SH2D1A, which can have inhibitory roles depending on context. Dysregulation of SH2D1B is associated with impaired innate immune responses, susceptibility to infections, and inflammatory disorders. Knockout studies reveal reduced NK cell function, impaired macrophage activation, and defective cytokine responses, highlighting its role in fine-tuning innate immunity and SLAM receptor signaling.
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