SH2 Domain Containing 1A (SH2D1A) Antibody
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Description
SH2D1A Antibody is a Rabbit Polyclonal antibody against SH2D1A. SH2D1A and SH2D1B are small, adaptor proteins with a single SH2-domain that play important signal transduction roles mediated by the signaling lymphocytic activation molecule (SLAM) family receptorsSH2D1A (also called SAP or SLAM-associated protein) is frequently mutated in patients with X-linked lymphoprolifeRative disease (Duncan’s disease), which is characterized by extreme susceptibility to Epstein-Barr virus; approximately 50 different SH2D1A mutations have been reported to dateThe single SH2D1B gene in humans (also called EAT-2 or Ewings sarcomas/FLI1-activated transcript 2) is present as a pair of duplicated EAT-2A and EAT-2B genes with identical genomic organization in mouse and Rat.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | SH2 Domain Containing 1A (SH2D1A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60880 |
| Gene ID | 4068 |
| Alias | SH2D1A,DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A,SLAM associated protein |
| Background | Antibody anti-SH2D1A |
| Status | RUO |
Descripción
SH2D1A, also known as SAP (SLAM-associated protein), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM (Signaling Lymphocyte Activation Molecule) family receptors. It is predominantly expressed in T cells, NK cells, and other immune cells, where it plays a crucial role in immune cell activation, cytotoxicity, and cytokine production. SH2D1A binds to the cytoplasmic tails of SLAM receptors, modulating T-cell receptor (TCR) signaling, NK cell activation, and germinal center formation. Mutations or deletions in SH2D1A cause X-linked lymphoproliferative syndrome (XLP), a severe immunodeficiency characterized by uncontrolled lymphocyte proliferation, impaired antibody responses, and susceptibility to Epstein-Barr virus (EBV) infections. SH2D1A also regulates immune synapse formation and T-cell-B-cell interactions, ensuring proper immune homeostasis. Knockout studies reveal defects in immune cell activation, abnormal germinal center development, and impaired antiviral responses, underscoring its essential role in immune regulation.
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