Sestrin 1 (SESN1) Antibody

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169€ (20 µg)

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935106861
info@markelab.com
name
Sestrin 1 (SESN1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx302551
tested applications
ELISA, WB, IHC

Description

SESN1 Antibody is a Rabbit Polyclonal against SESN1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Sestrin 1 (SESN1)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9Y6P5
Gene ID
27244
NCBI Accession
NP_001186862.1, NM_001199933.1
OMIM
606103
Alias
PA26,SEST1
Background
Antibody anti-SESN1
Status
RUO

Descripción

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SESN1 antibody

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway(PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein(By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(By similarity).

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