Mouse SESN1 (Sestrin 1) ELISA Kit
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Product specifications
| Category | ELISA Kits |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P58006 |
| Alias | Sestrin-1, p53-regulated protein PA26, SESN1, PA26, SEST1 |
| Background | Elisa kits for SESN1 |
| Status | RUO |
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SESN1 antibody
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway(PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein(By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(By similarity).
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