Serpin H1 (SERPINH1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Serpin H1 (SERPINH1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx148964
tested applications
ELISA, IHC
Description
Serpin H1 (SERPINH1) Antibody is a Rabbit Polyclonal antibody for the detection of HSP47.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serpin H1 (SERPINH1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P50454 |
| Gene ID | 871 |
| OMIM | 600943 |
| Alias | CBP1,CBP2,OI10,gp46,AsTP3,HSP47,PIG14,PPROM,RA-A47,SERPINH2,Serpin H1,Arsenic-transactivated protein 3,Collagen-binding protein,Colligin,Rheumatoid arthritis-related antigen,RA-A47,47 kDa heat shock protein |
| Background | Antibody anti-SERPINH1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
SERPINH1, also known as heat shock protein 47 (HSP47), is a member of the serpin (serine protease inhibitor) superfamily, though it functions differently from classical serpins. Unlike other serpins, SERPINH1 is not a protease inhibitor but rather acts as a molecular chaperone. It plays a crucial role in collagen biosynthesis, aiding the proper folding and stabilization of collagen molecules during their formation. As a collagen-specific chaperone, it is essential in maintaining the structural integrity of connective tissues and contributes significantly to tissue development and repair. The SERPINH1 gene is located on chromosome 11 in humans. Mutations in this gene have been associated with connective tissue disorders, notably osteogenesis imperfecta (OI), a condition characterized by fragile bones.
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