Serpin H1 (SERPINH1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Serpin H1 (SERPINH1) Immunogen: KLH-conjugated synthetic peptide between 169-196 amino acids from the Central region of human SERPINH1. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 46.4 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P50454 |
| Gene ID | 871 |
| OMIM | 600943 |
| Alias | CBP1,CBP2,OI10,gp46,AsTP3,HSP47,PIG14,PPROM,RA-A47,SERPINH2,Serpin H1,Arsenic-transactivated protein 3,Collagen-binding protein,Colligin,Rheumatoid arthritis-related antigen,RA-A47,47 kDa heat shock protein |
| Background | Antibody anti-SERPINH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SERPINH1, also known as heat shock protein 47 (HSP47), is a member of the serpin (serine protease inhibitor) superfamily, though it functions differently from classical serpins. Unlike other serpins, SERPINH1 is not a protease inhibitor but rather acts as a molecular chaperone. It plays a crucial role in collagen biosynthesis, aiding the proper folding and stabilization of collagen molecules during their formation. As a collagen-specific chaperone, it is essential in maintaining the structural integrity of connective tissues and contributes significantly to tissue development and repair. The SERPINH1 gene is located on chromosome 11 in humans. Mutations in this gene have been associated with connective tissue disorders, notably osteogenesis imperfecta (OI), a condition characterized by fragile bones.
Related Products
Serpin H1 (SERPINH1) Antibody
SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis.
Ver Producto
Human Serpin H1 (SERPINH1) ELISA Kit
Human Serpin H1 (SERPINH1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Serpin H1 (SERPINH1) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Serpin H1 (SERPINH1)
Ver Producto