Alpha-1-Antichymotrypsin (SERPINA3) Antibody
195€ (20 µl)
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935106861
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name
Alpha-1-Antichymotrypsin (SERPINA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000963
tested applications
ELISA, WB, IHC
Description
SERPINA3 Antibody is a Rabbit Polyclonal antibody against SERPINA3. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Alpha-1-Antichymotrypsin (SERPINA3) Immunogen: Recombinant protein corresponding to SERPINA3. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.3 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 48 kDa Observed MW: 50-76 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01011 |
| Gene ID | 12 |
| NCBI Accession | NP_001076.2, NM_001085.4 |
| OMIM | 107280 |
| Alias | ACT,AACT,GIG24,GIG25,Alpha-1-antichymotrypsin,Cell growth-inhibiting gene 24/25 protein,Serpin A3 |
| Background | Antibody anti-SERPINA3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
SERPINA3, also known as alpha-1 antichymotrypsin (ACT), is a member of the serine protease inhibitor (serpin) superfamily. The SERPINA3 gene is located on chromosome 14 (14q32.13), in close proximity to other serpin genes, including SERPINA1, which encodes alpha-1 antitrypsin. SERPINA3 plays a crucial role in inhibiting the activity of certain proteases, particularly cathepsin G and chymotrypsin, enzymes involved in inflammation and immune responses. The protein encoded by SERPINA3 is predominantly synthesized in the liver, but it is also expressed in various other tissues, including the brain, lungs, and immune cells. SERPINA3 has been implicated in a variety of physiological and pathological processes, such as inflammation, tissue remodeling, and the acute phase response. It is also known for its association with neurodegenerative diseases, particularly Alzheimer's disease, where it is found in amyloid plaques.
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