Human Alpha-1-Antichymotrypsin (SERPINA3) Protein
234€ (20 µg)
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name
Human Alpha-1-Antichymotrypsin (SERPINA3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx060928
Description
Human SERPINA3 is a native Human Protein isolated from normal Human Serum.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Alpha-1-Antichymotrypsin (SERPINA3) |
| Host | Human |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 68 kDa |
| Expression | Native |
| Purity | > 90%. Negative for HIV 1 and 2 antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies. |
| Purification | Purified from normal Human serum. |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in sterile 18 MΩ · cm water to a concentration of at least 1 mg/ml. This stock solution can be further diluted if required. |
| Buffer | Prior to lyophilization: 0.02 M Tris buffer, pH 7.5, containing 0.15 M NaCl. |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. For long-term storage, store between 2-8 °C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P01011 |
| Gene ID | 12 |
| NCBI Accession | NP_001076.2, NM_001085.4 |
| OMIM | 107280 |
| Alias | ACT,AACT,GIG24,GIG25,Alpha-1-antichymotrypsin,Cell growth-inhibiting gene 24/25 protein,Serpin A3 |
| Background | Protein SERPINA3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SERPINA3, also known as alpha-1 antichymotrypsin (ACT), is a member of the serine protease inhibitor (serpin) superfamily. The SERPINA3 gene is located on chromosome 14 (14q32.13), in close proximity to other serpin genes, including SERPINA1, which encodes alpha-1 antitrypsin. SERPINA3 plays a crucial role in inhibiting the activity of certain proteases, particularly cathepsin G and chymotrypsin, enzymes involved in inflammation and immune responses. The protein encoded by SERPINA3 is predominantly synthesized in the liver, but it is also expressed in various other tissues, including the brain, lungs, and immune cells. SERPINA3 has been implicated in a variety of physiological and pathological processes, such as inflammation, tissue remodeling, and the acute phase response. It is also known for its association with neurodegenerative diseases, particularly Alzheimer's disease, where it is found in amyloid plaques.
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Alpha-1-Antichymotrypsin (SERPINA3) Antibody
SERPINA3 is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
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