Serpin B3 (SERPINB3) Antibody
169€ (20 µg)
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name
Serpin B3 (SERPINB3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110205
tested applications
ELISA, IHC, IF/ICC
Description
Serpin B3 Antibody is a Rabbit Polyclonal antibody against Serpin B3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serpin B3 (SERPINB3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29508 |
| Gene ID | 6317 |
| NCBI Accession | NP_008850.1, NM_006919.2 |
| OMIM | 600517 |
| Alias | SCC,T4-A,SCCA1,SSCA1,SCCA-1,HsT1196,SCCA-PD,Serpin B3,Protein T4-A,Squamous cell carcinoma antigen 1 |
| Background | Antibody anti-SERPINB3 |
| Status | RUO |
Descripción
SERPINB3, also known as squamous cell carcinoma antigen 1 (SCCA1), is a member of the serine protease inhibitor (SERPIN) superfamily. This family of proteins plays critical roles in regulating various physiological processes, including inflammation, apoptosis, and immune responses. SERPINB3 was first identified due to its overexpression in squamous cell carcinomas, a type of skin cancer, which has made it a significant biomarker in oncology. The SERPINB3 gene is located on chromosome 18q21, where it resides in a cluster with several other SERPIN genes, including SERPINB4, with which it shares a high degree of homology. SERPINB3 is primarily expressed in epithelial tissues, particularly in the skin and mucous membranes. It is upregulated in response to various stressors, such as inflammation, hypoxia, and oxidative stress, indicating its role in cellular defense mechanisms.
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