Serpin A12 (SERPINA12) Antibody

Pida mas información

935106861

info@markelab.com

Precio

175€ (20 µl)

proveedor

Abbexa

reference

abx006608

Tested Applications

reactivity

Human, Mouse

status

RUO

clonality

Polyclonal

Descripción

SERPINA12 Antibody is a Rabbit Polyclonal Antibody against SERPINA12.

Background

Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL.). SERPINA12, a 47 kDa protease inhibitor from the adipokine family, has insulin-sensitizing properties. Its treatment in obese and insulin-resistant mice reduces insulin resistance gene expression in white adipose tissue and improves carbohydrate resistance.

Background

Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). SERPINA12, un inhibidor de la proteasa de 47 kDa de la familia de las adipocinas, tiene propiedades sensibilizadoras a la insulina. Su tratamiento en ratones obesos y resistentes a la insulina reduce la expresión del gen de resistencia a la insulina en el tejido adiposo blanco y mejora la resistencia a los carbohidratos.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Serpin A12 (SERPINA12)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

purification

Purified by affinity chromatography.

buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

size 1

20 µl

size 2

50 µl

size 3

100 µl

size 4

200 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SERPINA12

dry ice

availability

Shipped within 5-10 working days.

alias

Serpin A12,OL-64,Visceral adipose tissue-derived serine protease inhibitor,Vaspin,Visceral adipose-specific serpin

uniprot id

https://www.uniprot.org/uniprotkb/Q8IW75

gene id

https://www.ncbi.nlm.nih.gov/gene/145264

NCBI accession

NP_776249.1

note

This product is for research use only.

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