Human Serpin A12 (SERPINA12) ELISA Kit
proveedor
Abbexareference
abx153459Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Serpin A12 (SERPINA12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Serpin A12 (SERPINA12) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Serpin A12 (SERPINA12)No significant cross-reactivity or interference between Serpin A12 (SERPINA12) and analogues was observed.
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL.). SERPINA12, a 47 kDa protease inhibitor from the adipokine family, has insulin-sensitizing properties. Its treatment in obese and insulin-resistant mice reduces insulin resistance gene expression in white adipose tissue and improves carbohydrate resistance.
Background
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). SERPINA12, un inhibidor de la proteasa de 47 kDa de la familia de las adipocinas, tiene propiedades sensibilizadoras a la insulina. Su tratamiento en ratones obesos y resistentes a la insulina reduce la expresión del gen de resistencia a la insulina en el tejido adiposo blanco y mejora la resistencia a los carbohidratos.
Características del producto
category
ELISA Kits
immunogen target
Serpin A12 (SERPINA12)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SERPINA12
dry ice
No
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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