Serotonin receptor 2C Antibody
442€ (200 µl)
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name
Serotonin receptor 2C Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430982
tested applications
P-ELISA, WB
Description
Serotonin receptor 2C Antibody is a Goat Polyclonal antibody against Serotonin receptor 2C.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Serotonin receptor 2C Immunogen: abx269693 - Internal region: C-QVENLELPVN |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3358 |
| NCBI Accession | NP_000859.1 |
| Alias | HTR2C,HTR1C, 5-HT1C, 5-HT2C, 5HTR2C, 5-HTR2C,5-HT2C receptor |
| Background | Antibody anti-HTR2C |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
HTR2C is a serotonin receptor subtype located primarily in the central nervous system (CNS), particularly in the hypothalamus, choroid plexus, and limbic regions, where it regulates mood, appetite, and metabolic processes. As a G protein-coupled receptor (GPCR), HTR2C exerts its effects by activating intracellular signaling cascades, including the phospholipase C pathway. HTR2C plays a critical role in energy homeostasis and appetite suppression, contributing to its regulation of body weight. Agonism of HTR2C receptors promotes the release of pro-opiomelanocortin (POMC) in hypothalamic neurons, leading to reduced food intake and increased energy expenditure. Drugs such as lorcaserin, a selective HTR2C agonist, have been used to treat obesity by reducing appetite. HTR2C is also implicated in neuropsychiatric disorders, including depression, anxiety, schizophrenia, and substance abuse. Genetic polymorphisms and dysfunction in HTR2C signaling have been linked to metabolic syndrome, antipsychotic-induced weight gain, and insulin resistance, particularly in patients undergoing psychiatric treatments. Furthermore, HTR2C modulates dopaminergic and noradrenergic systems, which play roles in motivation, reward, and mood regulation. Its influence on behaviors such as impulsivity, cognition, and stress responses makes HTR2C a significant target for obesity management, mood stabilization, and substance use disorders. Understanding the therapeutic modulation of HTR2C holds promise for treating both metabolic and psychiatric conditions.
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