Serotonin receptor 1B Antibody
442€ (200 µl)
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name
Serotonin receptor 1B Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430978
tested applications
P-ELISA, WB
Description
Serotonin receptor 1B Antibody is a Goat Polyclonal antibody against Serotonin receptor 1B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Serotonin receptor 1B Immunogen: abx269910 - C-Terminus: C-SNEDFKQAFHK |
| Host | Goat |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3351, 15551, 25075 |
| NCBI Accession | NP_000854.1 |
| Alias | HTR1B,S12, 5-HT1B,HTR1D2, HTR1DB, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta,5-HT1B receptor |
| Background | Antibody anti-HTR1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
HTR1B, a subtype of the serotonin receptor family, is a G protein-coupled receptor (GPCR) responsible for mediating the effects of serotonin (5-HT), a neurotransmitter involved in mood, aggression, appetite, and sleep regulation. HTR1B is primarily expressed in the basal ganglia, hippocampus, cortex, and dorsal raphe nucleus, where it functions as both a presynaptic autoreceptor and a postsynaptic receptor. As an autoreceptor, HTR1B inhibits the release of serotonin, thereby regulating its availability at synapses. This negative feedback mechanism is critical for maintaining serotonin homeostasis and preventing overstimulation of neurons. HTR1B also modulates the release of other neurotransmitters, such as dopamine and acetylcholine, contributing to its role in motor control, mood stabilization, and reward pathways. Dysregulation of HTR1B has been implicated in mood disorders, such as depression, anxiety, and aggressive behaviors, as well as conditions like migraine headaches and substance abuse disorders. Pharmacological targeting of HTR1B, particularly through agonists or antagonists, has shown potential in alleviating symptoms of depression, migraine, and other serotonin-related disorders. Its role in modulating synaptic plasticity, neuroprotection, and neuronal signaling makes HTR1B a critical target for understanding and treating neuropsychiatric conditions.
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