Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230131
tested applications
ELISA, WB, IHC, FCM, IP
Description
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody is a Rabbit Polyclonal Antibody against Serine/threonine-Protein Kinase Receptor R3 (ACVRL1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/200 - 1/1000, IHC: 1/100 - 1/400, IP: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P37023 |
| Gene ID | 94 |
| OMIM | 600376 |
| Alias | Activin receptor-like kinase 1,ALK-1,SKR3 |
| Background | Antibody anti-ACVRL1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.
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