anti- ACVRL1 antibody

Name: anti- ACVRL1 antibody
Brand: FineTest
SKU: FNab00131
Availability: OnlineOnly

Este producto es parte de ACVR - Activin A Receptor Type

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-ACVRL1

proveedor

FineTest

reference

FNab00131

Tested Applications

ELISA, WB, IHC, FC, IP

reactivity

human

status

RUO

clonality

polyclonal

Descripción

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Background

ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.

Características del producto

clonality

polyclonal

reactivity

human

immunogen target

activin A receptor type II-like 1

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC, FC, IP

observerd MW

56 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:1000; IHC: 1:100-1:400; IP: 1:200-1:1000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

ACVRL1

alias

Activin receptor-like kinase 1,ALK-1,SKR3

uniprot id

https://www.uniprot.org/uniprotkb/P37023

gene id

https://www.ncbi.nlm.nih.gov/gene/94

note

This product is for research use only.

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