Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody

Este producto es parte de ACVR - Activin A Receptor Type
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52€ (10 µg)

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935106861
info@markelab.com
name
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx119055
tested applications
WB, IHC, IF/ICC

Description

Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody is a Rabbit Polyclonal against Serine/threonine-Protein Kinase Receptor R3 (ACVRL1).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
Validated in IF. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P37023
Alias
Activin receptor-like kinase 1,ALK-1,SKR3
Background
Antibody anti-ACVRL1
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.

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