Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
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Descripción del producto
Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody is a Rabbit Polyclonal Antibody against Serine/threonine-Protein Kinase Receptor R3 (ACVRL1).
Documents del producto
Especificaciones del producto
| Alias | Activin receptor-like kinase 1,ALK-1,SKR3 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-ACVRL1 |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 94 |
| Host | Rabbit |
| Immunogen Target | Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) |
| Isotype | IgG |
| Name | Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody |
| Price | 221 |
| Provider | Abbexa |
| Purification | Purified by affinity chromatography. |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx327694 |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB |
| UniProt ID | P37023 |
Descripcion del producto en español
Background en español
ACVRL1, also known as ALK1, is a type I receptor that primarily binds BMP9 and BMP10. It is critical for vascular development and endothelial cell function. ACVRL1 regulates angiogenesis through the SMAD1/5/8 signaling pathway, promoting endothelial proliferation and vessel stability. Mutations in ACVRL1 cause hereditary hemorrhagic telangiectasia (HHT), a genetic disorder characterized by abnormal blood vessel formation and recurrent bleeding. It is primarily expressed in vascular endothelial cells.
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anti- ACVRL1 antibody
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
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Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
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Serine/threonine-Protein Kinase Receptor R3 (ACVRL1) Antibody
ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
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