935106861
info@markelab.com
Precio
200€ (20 µl)
SQSTM1 Antibody is a Rabbit Polyclonal against SQSTM1.
SQSTM1, also known as p62, is an adaptor protein involved in selective autophagy, protein degradation, and cellular stress responses. It acts as a scaffold protein that interacts with ubiquitinated proteins and autophagy-related proteins like LC3, facilitating the delivery of misfolded or damaged proteins to the autophagosome for degradation. SQSTM1 also functions in signaling pathways such as NF-κB activation, oxidative stress responses, and mTOR signaling, where it regulates inflammation, apoptosis, and metabolism. It is highly expressed in various tissues and is essential for maintaining protein homeostasis under stress conditions. Dysregulation or mutations in SQSTM1 are associated with neurodegenerative diseases like ALS and Parkinson’s disease, Paget's disease of bone, and cancer due to impaired autophagy and accumulation of protein aggregates. Knockout studies reveal defects in autophagic flux, increased oxidative stress, and disrupted cellular homeostasis, underscoring its central role in protein quality control and cellular stress adaptation.
Primary Antibodies
Polyclonal
Human, Rat
Sequestosome 1 (SQSTM1)
Rabbit
Unconjugated
Liquid
WB, IHC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SQSTM1
No
Shipped within 5-10 working days.
SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, NADGP, DMRV
NP_003891.1
This product is for research use only.
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Ver másSQSTM1 Antibody is a Rabbit Polyclonal Antibody against SQSTM1.
175€ (20 µl)
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