Sequestosome 1 (SQSTM1) Antibody

Este producto es parte de SQSTM1 - Sequestosome-1
Sequestosome 1 (SQSTM1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

200€ (20 µl)

Antibody anti-SQSTM1

proveedor

Abbexa

reference

abx126645

Tested Applications

WB, IHC

reactivity

Human, Rat

status

RUO

clonality

Polyclonal

Descripción

SQSTM1 Antibody is a Rabbit Polyclonal against SQSTM1.


Background

SQSTM1, also known as p62, is an adaptor protein involved in selective autophagy, protein degradation, and cellular stress responses. It acts as a scaffold protein that interacts with ubiquitinated proteins and autophagy-related proteins like LC3, facilitating the delivery of misfolded or damaged proteins to the autophagosome for degradation. SQSTM1 also functions in signaling pathways such as NF-κB activation, oxidative stress responses, and mTOR signaling, where it regulates inflammation, apoptosis, and metabolism. It is highly expressed in various tissues and is essential for maintaining protein homeostasis under stress conditions. Dysregulation or mutations in SQSTM1 are associated with neurodegenerative diseases like ALS and Parkinson’s disease, Paget's disease of bone, and cancer due to impaired autophagy and accumulation of protein aggregates. Knockout studies reveal defects in autophagic flux, increased oxidative stress, and disrupted cellular homeostasis, underscoring its central role in protein quality control and cellular stress adaptation.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Rat


immunogen target

Sequestosome 1 (SQSTM1)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC


purification

Purified by affinity chromatography.


buffer

PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.


size 1

20 µl


size 2

50 µl


size 3

100 µl


size 4

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

SQSTM1


dry ice

No


availability

Shipped within 5-10 working days.


alias

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, NADGP, DMRV


NCBI accession

NP_003891.1


note

This product is for research use only.


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clonality

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