Sequestosome 1 Protein

Documentos del producto

Especificaciones del producto

Proteins and Peptides

SQSTM1

Activity: Not tested

Unconjugated

Recombinant

> 85% (SDS-PAGE)

5 µg

25 µg

1 mg

Liquid

SDS-PAGE

Shipped within 5-10 working days.

No

Q13501

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, NADGP, DMRV

Protein SQSTM1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

SQSTM1, also known as p62, is an adaptor protein involved in selective autophagy, protein degradation, and cellular stress responses. It acts as a scaffold protein that interacts with ubiquitinated proteins and autophagy-related proteins like LC3, facilitating the delivery of misfolded or damaged proteins to the autophagosome for degradation. SQSTM1 also functions in signaling pathways such as NF-κB activation, oxidative stress responses, and mTOR signaling, where it regulates inflammation, apoptosis, and metabolism. It is highly expressed in various tissues and is essential for maintaining protein homeostasis under stress conditions. Dysregulation or mutations in SQSTM1 are associated with neurodegenerative diseases like ALS and Parkinson’s disease, Paget's disease of bone, and cancer due to impaired autophagy and accumulation of protein aggregates. Knockout studies reveal defects in autophagic flux, increased oxidative stress, and disrupted cellular homeostasis, underscoring its central role in protein quality control and cellular stress adaptation.