Semaphorin 7A (SEMA7A) Antibody

Este producto es parte de SEMA7A - semaphorin 7A
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221€ (50 µg)

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935106861
info@markelab.com
name
Semaphorin 7A (SEMA7A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx327989
tested applications
ELISA, WB

Description

SEMA7A Antibody is a Rabbit Polyclonal against SEMA7A.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Semaphorin 7A (SEMA7A)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O75326
Gene ID
8482
Alias
JohnMiltonHagen blood group,JMH,CD108,SEMAL,CDw108,PFIC11,SEMAK1,H-Sema-L,H-SEMA-K1,JMH blood group antigen,Semaphorin-K1,Semaphorin-L
Background
Antibody anti-SEMA7A
Status
RUO

Descripción

Semaphorin 7A (SEMA7A) is a membrane-associated protein that belongs to the semaphorin family, a group of proteins widely recognized for their roles in axon guidance, immune response, and cellular signaling. Semaphorins, initially identified as axon-guidance molecules, are now understood to function across a variety of biological systems, impacting cell-cell interactions, cell migration, and immune cell regulation. SEMA7A, also referred to as CD108, is distinct from other semaphorins due to its glycophosphatidylinositol (GPI) anchorage, allowing it to localize on the cell surface and interact with various receptors. SEMA7A is broadly expressed in a range of tissues, including the nervous system, immune cells, skin, and certain cancer types. It is known to participate in axonal guidance, immune regulation, bone development, and pathological conditions, such as tumorigenesis and fibrotic diseases. One of its key functions is promoting axonal outgrowth and guiding neural connections, mediated through its interactions with integrins and other receptors. Furthermore, SEMA7A is actively involved in inflammatory and immune responses, modulating immune cell migration, adhesion, and activation. This diversity in function makes SEMA7A a molecule of interest in fields ranging from neurobiology to immunology and oncology.
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