Semaphorin-3F (SEMA3F) Antibody
169€ (20 µg)
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935106861
info@markelab.com
name
Semaphorin-3F (SEMA3F) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx346203
tested applications
ELISA, IHC
Description
Semaphorin-3F (SEMA3F) Antibody is a Rabbit Polyclonal antibody for the detection of Human SEMA3F.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Semaphorin-3F (SEMA3F) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13275 |
| Gene ID | 6405 |
| OMIM | 601124 |
| Alias | SEMA4,SEMAK,SEMA-IV,Sema III/F,Semaphorin-3F |
| Background | Antibody anti-SEMA3F |
| Status | RUO |
Descripción
SEMA3F (Semaphorin 3F) functions as a potent mediator of axonal guidance, angiogenesis, and tumor suppression. It exerts its effects primarily through interactions with neuropilin-2 (NRP2) and plexin receptors, inducing cytoskeletal changes that promote repulsion in axonal and endothelial cells. SEMA3F plays a pivotal role in neural development by regulating neuronal wiring and synaptic connectivity. In the vascular system, it acts as an anti-angiogenic factor, inhibiting abnormal vessel growth. Its expression is often downregulated in various cancers, correlating with increased tumor invasiveness and metastatic potential. Therapeutic strategies targeting SEMA3F aim to restore its expression to curb tumor progression and improve neural repair.
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