Human Semaphorin 3F (SEMA3F) Protein
208€ (10 µg)
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name
Human Semaphorin 3F (SEMA3F) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069027
tested applications
WB, SDS-PAGE
Description
Recombinant Semaphorin 3F (SEMA3F) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Semaphorin 3F (SEMA3F) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 21.6 kDa Observed MW (SDS-PAGE): 22 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn604-Thr785 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13275 |
| Alias | SEMA4,SEMAK,SEMA-IV,Sema III/F,Semaphorin-3F |
| Background | Protein SEMA3F |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SEMA3F (Semaphorin 3F) functions as a potent mediator of axonal guidance, angiogenesis, and tumor suppression. It exerts its effects primarily through interactions with neuropilin-2 (NRP2) and plexin receptors, inducing cytoskeletal changes that promote repulsion in axonal and endothelial cells. SEMA3F plays a pivotal role in neural development by regulating neuronal wiring and synaptic connectivity. In the vascular system, it acts as an anti-angiogenic factor, inhibiting abnormal vessel growth. Its expression is often downregulated in various cancers, correlating with increased tumor invasiveness and metastatic potential. Therapeutic strategies targeting SEMA3F aim to restore its expression to curb tumor progression and improve neural repair.
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