Semaphorin 3D (SEMA3D) Antibody

Background

SEMA3D (Semaphorin 3D) is a critical player in axon guidance, cellular migration, and vascular patterning. It primarily functions through interaction with neuropilin-1 (NRP1) and plexin receptors, facilitating repulsive guidance in neuronal circuits and vascular development. SEMA3D is particularly significant in embryogenesis, where it orchestrates tissue morphogenesis and organ development. Beyond its developmental roles, SEMA3D is associated with cancer biology, where altered expression has been linked to tumor progression and metastasis. Its ability to influence angiogenesis and cellular motility positions it as a promising target for therapeutic strategies in cancer and vascular diseases.