anti- SEMA3D antibody
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935106861
info@markelab.com
name
anti- SEMA3D antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07707
tested applications
ELISA
Description
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | sema domain, immunoglobulin domain(Ig), short basic domain, secreted,(semaphorin) 3D |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O95025 |
| Gene ID | 223117 |
| Alias | coll-2,Sema-Z2,Semaphorin-3D |
| Background | Antibody anti-SEMA3D |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
SEMA3D (Semaphorin 3D) is a critical player in axon guidance, cellular migration, and vascular patterning. It primarily functions through interaction with neuropilin-1 (NRP1) and plexin receptors, facilitating repulsive guidance in neuronal circuits and vascular development. SEMA3D is particularly significant in embryogenesis, where it orchestrates tissue morphogenesis and organ development. Beyond its developmental roles, SEMA3D is associated with cancer biology, where altered expression has been linked to tumor progression and metastasis. Its ability to influence angiogenesis and cellular motility positions it as a promising target for therapeutic strategies in cancer and vascular diseases.
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