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Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin(By similarity).
SEMA3D (Semaphorin 3D) is a critical player in axon guidance, cellular migration, and vascular patterning. It primarily functions through interaction with neuropilin-1 (NRP1) and plexin receptors, facilitating repulsive guidance in neuronal circuits and vascular development. SEMA3D is particularly significant in embryogenesis, where it orchestrates tissue morphogenesis and organ development. Beyond its developmental roles, SEMA3D is associated with cancer biology, where altered expression has been linked to tumor progression and metastasis. Its ability to influence angiogenesis and cellular motility positions it as a promising target for therapeutic strategies in cancer and vascular diseases.
Primary Antibodies
polyclonal
human,mouse,rat
sema domain, immunoglobulin domain(Ig), short basic domain, secreted,(semaphorin) 3D
Rabbit
IgG
Unconjugated
liquid
ELISA
≥95% as determined by SDS-PAGE
Immunogen affinity purified
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
SEMA3D
coll-2,Sema-Z2,Semaphorin-3D
This product is for research use only.
Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neu...
250€ (80 µl)
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