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Semaphorin 3C (SEMA3C) Antibody
proveedor
Abbexareference
abx326559Tested Applications
ELISA, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
SEMA3C Antibody is a Rabbit Polyclonal against SEMA3C.
Background
Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. SEMA3C binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. Elevated expression of this gene is associated with an increase in cancer cell invasion and adhesion. It is also known by aliases such as SemE and SEMAE.
Background
Las semaforinas constituyen una gran familia de moléculas guía secretadas y de superficie celular, clasificadas en ocho clases debido a sus variaciones estructurales. Muestran un dominio sema conservado en su región N-terminal. Funcionan principalmente como señales inhibidoras de corto alcance, particularmente cruciales para alejar los axones de áreas inapropiadas, especialmente durante el desarrollo del sistema neuronal. Las plexinas son los receptores principales de las semaforinas y a menudo trabajan junto con las neuropilinas como correceptores en complejos receptores. Estas moléculas tienen varias funciones y algunas clases de semaforinas (SEMA3, SEMA4, SEMA4, SEMA6, SEMA7) se encuentran en los vertebrados y contribuyen a procesos como la aterosclerosis al afectar la función endotelial, la infiltración de leucocitos, la retención de monocitos y macrófagos, la hiperreactividad plaquetaria y la neovascularización. . SEMA3C se une a un correceptor de neuropilina antes de formar un complejo heterotrimérico con una plexina asociada. La expresión elevada de este gen se asocia con un aumento en la invasión y adhesión de células cancerosas. También es conocido por alias como SemE y SEMAE.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Semaphorin 3C (SEMA3C)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IHC
purification
Purified by affinity chromatography.
buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SEMA3C
dry ice
No
availability
Shipped within 5-10 working days.
alias
SemE,SEMAE,Semaphorin-E
uniprot id
note
This product is for research use only.
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