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Chicken Semaphorin 3C (SEMA3C) ELISA Kit
proveedor
Abbexareference
abx519936Tested Applications
ELISAreactivity
Chickenstatus
RUOclonality
Descripción
Chicken Semaphorin 3C (SEMA3C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Chicken Semaphorin 3C concentrations in serum, plasma and other biological fluids.
Background
Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. SEMA3C binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. Elevated expression of this gene is associated with an increase in cancer cell invasion and adhesion. It is also known by aliases such as SemE and SEMAE.
Background
Las semaforinas constituyen una gran familia de moléculas guía secretadas y de superficie celular, clasificadas en ocho clases debido a sus variaciones estructurales. Muestran un dominio sema conservado en su región N-terminal. Funcionan principalmente como señales inhibidoras de corto alcance, particularmente cruciales para alejar los axones de áreas inapropiadas, especialmente durante el desarrollo del sistema neuronal. Las plexinas son los receptores principales de las semaforinas y a menudo trabajan junto con las neuropilinas como correceptores en complejos receptores. Estas moléculas tienen varias funciones y algunas clases de semaforinas (SEMA3, SEMA4, SEMA4, SEMA6, SEMA7) se encuentran en los vertebrados y contribuyen a procesos como la aterosclerosis al afectar la función endotelial, la infiltración de leucocitos, la retención de monocitos y macrófagos, la hiperreactividad plaquetaria y la neovascularización. . SEMA3C se une a un correceptor de neuropilina antes de formar un complejo heterotrimérico con una plexina asociada. La expresión elevada de este gen se asocia con un aumento en la invasión y adhesión de células cancerosas. También es conocido por alias como SemE y SEMAE.
Características del producto
category
ELISA Kits
immunogen target
Semaphorin 3C (SEMA3C)
reactivity
Chicken
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
alias
SemE,SEMAE,Semaphorin-E
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SEMA3C
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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