SAM and SH3 domain-containing protein 1 (SASH1) Antibody (HRP)

Este producto es parte de SASH - SAM and SH3 domain containing
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169€ (20 µg)

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935106861
info@markelab.com
name
SAM and SH3 domain-containing protein 1 (SASH1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx344412
tested applications
ELISA

Description

SAM and SH3 domain-containing protein 1 (SASH1) Antibody (HRP) is a Rabbit Polyclonal antibody conjugated to HRP for the detection of Human SASH1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
SAM and SH3 domain-containing protein 1 (SASH1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G chromatography.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O94885
Gene ID
23328
OMIM
127500
Alias
CAPOK,DUH,DUH1,SH3D6A,dJ323M4.1,Proline-glutamate repeat-containing protein
Background
Antibody anti-SASH1
Status
RUO

Descripción

SAM and SH3 domain containing 1 (SASH1) is a scaffolding protein that functions as a tumor suppressor and a signaling adaptor in cellular processes such as adhesion, migration, and proliferation SASH1 contains SAM (Sterile Alpha Motif) and SH3 (Src Homology 3) domains that enable interactions with signaling molecules, linking it to pathways regulating cytoskeletal organization, inflammation, and apoptosis It is predominantly expressed in epithelial tissues and immune cells, where it modulates cell-cell adhesion and response to extracellular signals Loss or downregulation of SASH1 expression is associated with tumor progression, invasion, and poor prognosis in cancers such as breast, colorectal, and lung cancers, underscoring its role in suppressing metastasis SASH1 is also involved in regulating inflammatory pathways and immune responses, suggesting its broader role in maintaining tissue homeostasis Emerging studies highlight its importance in vascular remodeling and wound healing, where it influences endothelial cell function Its ability to interact with multiple signaling pathways makes SASH1 a key regulator of cell behavior and a potential therapeutic target in cancer and inflammatory diseases

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