SAM And SH3 Domain-Containing Protein 1 (SASH1) Antibody
260€ (50 µl)
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Name
SAM And SH3 Domain-Containing Protein 1 (SASH1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211856
Tested Applications
ELISA, WB, IHC
Description
SASH1 Antibody is a Rabbit Polyclonal against SASH1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SAM And SH3 Domain-Containing Protein 1 (SASH1) Immunogen: Synthetic peptide of human SASH1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94885 |
| Gene ID | 23328 |
| Alias | CAPOK,DUH,DUH1,SH3D6A,dJ323M4.1,Proline-glutamate repeat-containing protein |
| Background | Antibody anti-SASH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SAM and SH3 domain containing 1 (SASH1) is a scaffolding protein that functions as a tumor suppressor and a signaling adaptor in cellular processes such as adhesion, migration, and proliferation SASH1 contains SAM (Sterile Alpha Motif) and SH3 (Src Homology 3) domains that enable interactions with signaling molecules, linking it to pathways regulating cytoskeletal organization, inflammation, and apoptosis It is predominantly expressed in epithelial tissues and immune cells, where it modulates cell-cell adhesion and response to extracellular signals Loss or downregulation of SASH1 expression is associated with tumor progression, invasion, and poor prognosis in cancers such as breast, colorectal, and lung cancers, underscoring its role in suppressing metastasis SASH1 is also involved in regulating inflammatory pathways and immune responses, suggesting its broader role in maintaining tissue homeostasis Emerging studies highlight its importance in vascular remodeling and wound healing, where it influences endothelial cell function Its ability to interact with multiple signaling pathways makes SASH1 a key regulator of cell behavior and a potential therapeutic target in cancer and inflammatory diseases
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