SAM and SH3 Domain-Containing Protein 1 (SASH1) Antibody
364€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
SAM and SH3 Domain-Containing Protein 1 (SASH1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx240168
Tested Applications
ELISA, WB
Description
SAM and SH3 Domain-Containing Protein 1 (SASH1) Antibody is a Rabbit Polyclonal antibody for the detection of SASH1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: SAM and SH3 Domain-Containing Protein 1 (SASH1) Immunogen: SAM and SH3 domain-containing protein 1 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 170 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O94885 |
| Gene ID | 23328 |
| OMIM | 127500 |
| Alias | CAPOK,DUH,DUH1,SH3D6A,dJ323M4.1,Proline-glutamate repeat-containing protein |
| Background | Antibody anti-SASH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SAM and SH3 domain containing 1 (SASH1) is a scaffolding protein that functions as a tumor suppressor and a signaling adaptor in cellular processes such as adhesion, migration, and proliferation SASH1 contains SAM (Sterile Alpha Motif) and SH3 (Src Homology 3) domains that enable interactions with signaling molecules, linking it to pathways regulating cytoskeletal organization, inflammation, and apoptosis It is predominantly expressed in epithelial tissues and immune cells, where it modulates cell-cell adhesion and response to extracellular signals Loss or downregulation of SASH1 expression is associated with tumor progression, invasion, and poor prognosis in cancers such as breast, colorectal, and lung cancers, underscoring its role in suppressing metastasis SASH1 is also involved in regulating inflammatory pathways and immune responses, suggesting its broader role in maintaining tissue homeostasis Emerging studies highlight its importance in vascular remodeling and wound healing, where it influences endothelial cell function Its ability to interact with multiple signaling pathways makes SASH1 a key regulator of cell behavior and a potential therapeutic target in cancer and inflammatory diseases
Productos relacionados
SAM And SH3 Domain-Containing Protein 1 (SASH1) Antibody
SASH1 may have a role in a signaling pathway and could act as a tumor suppressor.…
Ver producto
Mouse Sash1 Antibody
Sash1 may have a role in a signaling pathway. Could act as a tumor suppressor.…
Ver producto
SAM And SH3 Domain-Containing Protein 1 (SASH1) Antibody
SASH1 Antibody is a Rabbit Polyclonal against SASH1.…
Ver producto