Roundabout Homolog 1 (ROBO1) Antibody
299€ (50 µl)
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935106861
info@markelab.com
name
Roundabout Homolog 1 (ROBO1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402456
tested applications
ELISA, IHC, IF/ICC, FCM
Description
Roundabout Homolog 1 (ROBO1) Antibody is a Recombinant Mouse Monoclonal antibody for the detection of Human ROBO1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Roundabout Homolog 1 (ROBO1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200, FCM: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC, FCM |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y6N7 |
| Gene ID | 6091 |
| OMIM | 602430 |
| Alias | NORS,NYS8,SAX3,CPHD8,DUTT1,Deleted in U twenty twenty,H-Robo-1,Roundabout homolog 1 |
| Background | Antibody anti-ROBO1 |
| Status | RUO |
Descripción
ROBO1 (Roundabout Guidance Receptor 1) is a key transmembrane protein implicated in axon guidance during neural development, where it functions as a receptor for Slit family proteins. Through its interaction with Slit ligands, ROBO1 mediates axonal repulsion, which is critical for establishing neural circuits and ensuring proper brain organization. It is also involved in regulating cell migration, particularly in processes such as angiogenesis and tumorigenesis, by modulating cytoskeletal dynamics. Dysregulation or mutations in ROBO1 have been associated with neurological disorders and cancer progression, emphasizing its significance in both developmental and pathological contexts.
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