Roundabout Homolog 3 (ROBO3) Antibody
357.5€ (100 µg)
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name
Roundabout Homolog 3 (ROBO3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145585
tested applications
ELISA, WB, IHC
Description
ROBO3 Antibody is a Rabbit Polyclonal against ROBO3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Roundabout Homolog 3 (ROBO3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96HH0 |
| Gene ID | 64221 |
| NCBI Accession | BC008623 |
| OMIM | 607313 |
| Alias | HGPS,RIG1,HGPPS,RBIG1,HGPPS1,Roundabout-like protein 3,Roundabout homolog 3 |
| Background | Antibody anti-ROBO3 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ROBO3 (Roundabout Guidance Receptor 3) is a unique member of the Roundabout receptor family with critical roles in axon guidance and neural development. Unlike other ROBO proteins, ROBO3 facilitates the crossing of axons at the midline of the central nervous system by antagonizing Slit-mediated repulsion, a process essential for the development of bilateral neural circuits. ROBO3 expression is tightly regulated during neural development, and mutations in the ROBO3 gene have been linked to horizontal gaze palsy with progressive scoliosis, a rare congenital disorder affecting motor control and spinal development. This receptor’s ability to modulate axon guidance makes it indispensable for proper neural wiring and functional brain organization.
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