Roundabout Homolog 1 (ROBO1) Antibody

Este producto es parte de ROBO - roundabout guidance receptor
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Roundabout Homolog 1 (ROBO1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx340092
tested applications
ELISA, WB, IHC

Description

ROBO1 Antibody is a Rabbit Polyclonal against ROBO1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetRoundabout Homolog 1 (ROBO1)
HostRabbit
ReactivityHuman
Recommended DilutionELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by antigen affinity column chromatography.
Size 1100 µg
Size 21 mg
FormLyophilized
Tested ApplicationsELISA, WB, IHC
BufferPrior to lyophilization: 1% BSA and 0.02% NaN3.
AvailabilityShipped within 7-15 working days.
StorageStore at -20 °C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ9Y6N7
Gene ID6091
NCBI AccessionBC112336
OMIM602430
AliasNORS,NYS8,SAX3,CPHD8,DUTT1,Deleted in U twenty twenty,H-Robo-1,Roundabout homolog 1
BackgroundAntibody anti-ROBO1
StatusRUO
NoteConcentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -

Descripción

ROBO1 (Roundabout Guidance Receptor 1) is a key transmembrane protein implicated in axon guidance during neural development, where it functions as a receptor for Slit family proteins. Through its interaction with Slit ligands, ROBO1 mediates axonal repulsion, which is critical for establishing neural circuits and ensuring proper brain organization. It is also involved in regulating cell migration, particularly in processes such as angiogenesis and tumorigenesis, by modulating cytoskeletal dynamics. Dysregulation or mutations in ROBO1 have been associated with neurological disorders and cancer progression, emphasizing its significance in both developmental and pathological contexts.
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