ROBO3-Specific Antibody
377€ (100 µg)
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Name
ROBO3-Specific Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx237374
Tested Applications
ELISA, WB, IHC
Description
ROBO3-Specific Antibody is a Rabbit Polyclonal against ROBO3-Specific.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ROBO3-Specific Immunogen: roundabout, axon guidance receptor, homolog 3 (Drosophila) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 55 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96MS0 |
| Gene ID | 64221 |
| OMIM | 607313 |
| Alias | HGPS,RIG1,HGPPS,RBIG1,HGPPS1,Roundabout-like protein 3,Roundabout homolog 3 |
| Background | Antibody anti-ROBO3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ROBO3 (Roundabout Guidance Receptor 3) is a unique member of the Roundabout receptor family with critical roles in axon guidance and neural development. Unlike other ROBO proteins, ROBO3 facilitates the crossing of axons at the midline of the central nervous system by antagonizing Slit-mediated repulsion, a process essential for the development of bilateral neural circuits. ROBO3 expression is tightly regulated during neural development, and mutations in the ROBO3 gene have been linked to horizontal gaze palsy with progressive scoliosis, a rare congenital disorder affecting motor control and spinal development. This receptor’s ability to modulate axon guidance makes it indispensable for proper neural wiring and functional brain organization.
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