RNA Polymerase III Subunit A (POLR3A) Antibody
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Description
Polymerase (Rna) Iii (Dna Directed) Polypeptide A, 155Kda Antibody is a Rabbit Polyclonal antibody against Polymerase (Rna) Iii (Dna Directed) Polypeptide A, 155Kda.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RNA Polymerase III Subunit A (POLR3A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14802 |
| Gene ID | 11128 |
| OMIM | 264090 |
| Background | Antibody anti-POLR3A |
| Status | RUO |
Descripción
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POLR3A antibody
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition(By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
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RNA Polymerase III Subunit A (POLR3A) Antibody
Polymerase (Rna) Iii (Dna Directed) Polypeptide A, 155Kda Antibody is a Rabbit Polyclonal antibody against Polymerase (Rna) Iii (Dna Directed) Polypeptide A, 155Kda.
Ver Producto
RNA Polymerase III Subunit A (POLR3A) Antibody
POLR3A Antibody is a Rabbit Polyclonal against POLR3A.
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