Rho Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rho guanine nucleotide exchange factor 18 Antibody is a Rabbit Polyclonal antibody against Rho guanine nucleotide exchange factor 18.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Rho Guanine Nucleotide Exchange Factor 18 (ARHGEF18) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purity | > 95% |
Purification | Purified by Protein G. |
Size 1 | 20 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 1 mg |
Form | Liquid |
Tested Applications | ELISA, WB |
Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q6ZSZ5 |
Gene ID | 23370 |
NCBI Accession | NP_001124427.1, NM_001130955.1 |
OMIM | 616432 |
Background | Antibody anti-ARHGEF18 |
Status | RUO |
Descripción
Related Products

anti- ARHGEF18 antibody
Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).
Ver Producto
Rho Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Antibody
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
Ver Producto
Rho Guanine Nucleotide Exchange Factor 18 (ARHGEF18) Antibody (Biotin)
Rho guanine nucleotide exchange factor 18 Antibody (Biotin) is a Rabbit Polyclonal antibody against Rho guanine nucleotide exchange factor 18 conjugated to Biotin.
Ver Producto