ARHGEF18 antibody
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Description
Acts as guanine nucleotide exchange factor(GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species(ROS). Does not act as a GEF for CDC42. The G protein beta-gamma(Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells(PubMed:22006950).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | rho/rac guanine nucleotide exchange factor(GEF) 18 (ARHGEF18) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120-130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q6ZSZ5 |
| Gene ID | 23370 |
| Alias | Rho guanine nucleotide exchange factor 18,114 kDa Rho-specific guanine nucleotide exchange factor (p114-Rho-GEF, p114RhoGEF),Septin-associated RhoGEF (SA-RhoGEF),ARHGEF18,KIAA0521 |
| Background | Antibody anti-ARHGEF18 |
| Status | RUO |
| Note | Mol. Weight 120-130 kDa |
Descripción
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