Retinoid X Receptor Alpha (RXRA) Antibody
292.5€ (80 µl)
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Name
Retinoid X Receptor Alpha (RXRA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx032344
Tested Applications
ELISA, WB, IHC
Description
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Retinoid X Receptor Alpha (RXRA) Immunogen: KLH-conjugated synthetic peptide between 196-224 amino acids from the Central region of human RXRA. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 50.8 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19793 |
| Alias | NR2B1,RXRalpha,RXR-alpha,Retinoic acid receptor RXR-alpha,Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| Background | Antibody anti-RXRA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Retinoid X receptor alpha (RXRA) is a nuclear receptor that plays a crucial role in regulating gene expression in response to retinoids, which are derived from vitamin A RXRA forms heterodimers with other nuclear receptors, such as the retinoic acid receptor (RAR) and peroxisome proliferator-activated receptors (PPARs), to regulate genes involved in processes such as cell differentiation, metabolism, and immune responses RXRA is involved in the regulation of lipid metabolism, glucose homeostasis, and cellular growth and differentiation It also plays a role in the development and maintenance of the central nervous system and immune system RXRA’s activity is essential for maintaining metabolic balance and preventing diseases like cancer, cardiovascular disease, and metabolic disorders, as it regulates critical pathways in cellular growth and lipid homeostasis Dysregulation of RXRA signaling has been linked to various cancers, including breast and prostate cancers, as well as metabolic diseases and disorders related to vitamin A deficiency RXRA is also a target for therapies aimed at controlling metabolic and inflammatory diseases
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