Retinoic Acid Receptor Beta (RARb) Antibody
286€ (100 µl)
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Name
Retinoic Acid Receptor Beta (RARb) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx131126
Tested Applications
WB, IHC, IF/ICC
Description
Retinoic Acid Receptor Beta Antibody is a Rabbit Polyclonal against Retinoic Acid Receptor Beta.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Retinoic Acid Receptor Beta (RARb) Immunogen: RARb (Leu205-Ser451) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10826 |
| Alias | HAP,RRB2,NR1B2,MCOPS12,RARbeta,RARbeta1,HBV-activated protein,Nuclear receptor subfamily 1 group B member 2,RAR-epsilon |
| Background | Antibody anti-RARB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Retinoic acid receptor beta (RARB) is another member of the retinoic acid receptor family that regulates gene expression in response to retinoic acid It plays a significant role in controlling cellular processes such as differentiation, growth, and apoptosis, particularly in tissues like the retina, lung, and skin RARB functions by forming heterodimers with RXR and binding to RAREs, where it modulates the expression of genes involved in various biological processes, including the development and maintenance of the central nervous system and the immune system It is particularly important for vision and retinal function, where it helps in the differentiation of photoreceptor cells Retinoic acid signaling through RARB also affects cancer development, as altered RARB expression has been linked to tumor progression, particularly in lung, breast, and colon cancers In addition, changes in RARB signaling have been implicated in autoimmune diseases and neurological disorders, highlighting its importance in both immune function and nervous system development
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