Retinal Dehydrogenase 1 (ALDH1A1) Antibody

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
Retinal Dehydrogenase 1 (ALDH1A1) Antibody

Pida mas información

935106861

info@markelab.com

Precio

362.5€ (100 µl)

Antibody anti-ALDH1A1

proveedor

Abbexa

reference

abx010374

Tested Applications

ELISA, WB, IHC

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros.


Background

ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Retinal Dehydrogenase 1 (ALDH1A1)


host

Mouse


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB, IHC


purification

Unpurified ascites.


buffer

Ascitic fluid containing 0.03% sodium azide.


size 1

100 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ALDH1A1


dry ice

No


availability

Shipped within 5-10 working days.


alias

3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII


note

This product is for research use only.


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