Retinal Dehydrogenase 1 (ALDH1A1) Antibody
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935106861
info@markelab.com
Precio
362.5€ (100 µl)
Antibody anti-ALDH1A1
proveedor
Abbexareference
abx010374Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
ALDH1A1 is an aldehyde dehydrogenase able to oxidize a wide variety of aliphatic aldehydes (retinaldehyde, acetaldehyde, etc.) to the corresponding carboxylic acids (retinoic acid, acetic acid, etc.). ALDH1A1 (also known as RALDH1, ALDH1, or AHD2) is highly expressed in the dorsal retina, ventral midbrain (dopaminergic neurons), and hematopoietic stem cells. ALDH1A1 is involved in retinoic acid (RA) synthesis during vertebrate embryogenesis. ALDH1A1 is first detected at E9.0-E10.5 in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, optic vesicles) and in the mesonephros.
Background
ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Retinal Dehydrogenase 1 (ALDH1A1)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Unpurified ascites.
buffer
Ascitic fluid containing 0.03% sodium azide.
size 1
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ALDH1A1
dry ice
No
availability
Shipped within 5-10 working days.
alias
3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII
uniprot id
note
This product is for research use only.
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